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July 18-August 5

Parkman Bandstand, Boston Common

By William Shakespeare

Directed by Steven Maler

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Schedule
Wednesday, July 18 at 8:00pm Thursday, July 19 at 8:00pm Friday, July 20 at 8:00pm Saturday, July 21 at 8:00pm Sunday, July 22 at 7:00pm

P erformances are FREE and open to the public. Tuesday –Saturday at 8pm, Sundays at 7pm (off Mondays) Matinee performance on Saturday, August 4 at 3pm

Accessibility Performances: Audio Described Performance: Saturday, August 4 at 3pm (rain date: Sunday, August 5) Open Captioned: Saturday, July 28 at 8pm (Rain Date: Wednesday, August 1) ASL (American Sign Language) dates coming soon!

Accessibility Performances:

Plan Your Trip including Parking, Accessibility and FAQ’s!

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Shakespeare’s searing drama chronicles the ruthless ascension of a king and the devastation he leaves in his wake as he gains power over the realm.Featuring stage, film, and television actor, Faran Tahir as Richard III.

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$60 Friend Section Chairs Chairs are a $60 donation until July 17 and then increase to $75during performance weeks.

$60 Friend Section Chairs
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Free Shakespeare on the Common is made possible each year through a combination of grants, sponsorships, and donations collected through the Friends Section program. The Friends Section consists of lawn chairs set in front of the stage for your convenience. Individuals can reserve a chair at a performance with a donation of $60 per chair, with all proceeds going directly towards the cost of the production. After July 17th, chairs increase to $75 during performance weeks. Online reservations can be made up to 5 hours prior to the performance.

Individuals can reserve a chair at a performance with a donation of $60 per chair, with all proceeds going directly towards the cost of the production. After July 17th, chairs increase to $75 during performance weeks.

Friends Section chairs are preassigned.You will be seated at the performance by a member of our team.You must select the performance date you would like to attend at time of purchase or seats will not be reserved.

All donations are NON-REFUNDABLE and NON-TRANSFERABLE. Proceeds from the Friends Section help keep Shakespeare on the Common free for all!

in the meaning defined at sense 1

fundamental

Definition of for English Language Learners

fundamental

Definition of for English Language Learners

1

fundamental

adjective fun·da·men·tal \ ˌfən-də-ˈmen-tᵊl \
: being or forming a foundation : basic , Cheap 2018 Newest Escada Sleeveless Wool Dress Cheap Original Clearance Cheapest Buy Cheap Amazon Outlet Affordable oIrN1

fundamentally

adverb
2

fundamental

: a basic part

fundamental

fun·da·men·tal \ ˌfən-də-ˈment-ᵊl \
: the principal musical tone produced by vibration (as of a string or column of air) on which a series of higher overtones is based

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halcyon

peaceful, happy, or prosperous

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Juan María Jurado , Dubái

Hace años que queremos hacer de Barcelona una ciudad más Welcome Friendly, pero sigue habiendo muchas barreras en el proceso de acogida que no hacen más que transmitir una mala imagen de la ciudad hacia el exterior y que lastran la atracción de talento.

Barcelona

Barreras en el proceso de acogida

Hace años que queremos hacer de Barcelona una ciudad más Welcome Friendly , es decir, que sea lo más amigable posible en la llegada e integración de los nuevos barceloneses, el nuevo talento que queremos atraer a nuestra ciudad. Sin embargo, sigue habiendo muchas barreras en el proceso de acogida que no hacen más que transmitir una mala imagen de Barcelona hacia el exterior y que lastran la atracción de talento. Se trata de ámbitos tan sabidos como la burocracia en la obtención de documentación oficial y permisos, los impuestos y las múltiples tasas a pagar, la ayuda a la hora del acceso a la vivienda accesible, la seguridad, y la tremenda barrera del idioma: el business y el talento hablan en inglés y esto debe plasmarse tanto en las escuelas como en la administración.

Dubái

¿Por qué Dubái es una de las ciudades del mundo que más talento atrae?

¿Por qué Dubái es una de las ciudades del mundo que más talento atrae? Los perjuicios que surgen cuando te ofrecen este destino profesional desaparecen solo llegar: multitud de empresas de relocation te ayudan a gestionar la burocracia de entrada al país, búsqueda de vivienda, colegios, seguro médico, etc; existen muchas apps para facilitar servicios -pago y gestión de recibos, transporte público y taxi, entregas a domicilio, entre otras-; así como infinidad de restaurantes, hoteles y actividades de ocio (muchas para niños) y productos de todas las regiones del mundo en los supermercados. La gestión de servicios gubernamentales es rápida y eficiente (ID y carnet de conducir al momento, etc) y se respira un alto nivel de seguridad. Además, las facilidades fiscales y financieras planteadas para las empresas y empleados ayudan a atraer a los mejores profesionales.

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Original Article Free Preview

Drs. Jongen-Lavrencic and Grob and Ms. Hanekamp and Drs. Schuurhuis, Löwenberg, and Valk contributed equally to this article.

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N Engl J Med 2018; 378:1189-1199 DOI: 10.1056/NEJMoa1716863

Abstract

Patients with acute myeloid leukemia (AML) often reach complete remission, but relapse rates remain high. Next-generation sequencing enables the detection of molecular minimal residual disease in virtually every patient, but its clinical value for the prediction of relapse has yet to be established.

We conducted a study involving patients 18 to 65 years of age who had newly diagnosed AML. Targeted next-generation sequencing was carried out at diagnosis and after induction therapy (during complete remission). End points were 4-year rates of relapse, relapse-free survival, and overall survival.

At least one mutation was detected in 430 out of 482 patients (89.2%). Mutations persisted in 51.4% of those patients during complete remission and were present at various allele frequencies (range, 0.02 to 47%). The detection of persistent DTA mutations (i.e., mutations in DNMT3A, TET2, and ASXL1), which are often present in persons with age-related clonal hematopoiesis, was not correlated with an increased relapse rate. After the exclusion of persistent DTA mutations, the detection of molecular minimal residual disease was associated with a significantly higher relapse rate than no detection (55.4% vs. 31.9%; hazard ratio, 2.14; P<0.001), as well as with lower rates of relapse-free survival (36.6% vs. 58.1%; hazard ratio for relapse or death, 1.92; P<0.001) and overall survival (41.9% vs. 66.1%; hazard ratio for death, 2.06; P<0.001). Multivariate analysis confirmed that the persistence of non-DTA mutations during complete remission conferred significant independent prognostic value with respect to the rates of relapse (hazard ratio, 1.89; P<0.001), relapse-free survival (hazard ratio for relapse or death, 1.64; P=0.001), and overall survival (hazard ratio for death, 1.64; P=0.003). A comparison of sequencing with flow cytometry for the detection of residual disease showed that sequencing had significant additive prognostic value.

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